目的 研究3-氨基-2-[(2'-氰基联苯-4-基)甲基]氨基-苯甲酸乙酯的最优合成工艺。方法 以2-[(2'-氰基联苯-4-基)-甲基]氨基-3-硝基苯甲酸乙酯为原料，水合肼为还原剂，Pb/C为催化剂，还原制得。结果 原料与还原剂的最佳物质的量比为1.92∶1，催化剂Pd/C为1.2 g，反应温度为75 ℃，反应时间2 h的最优条件下，收率为92.0%。结论 本合成工艺稳定，条件温和，产率高，适合3-氨基-2-[(2'-氰基联苯-4-基)甲基]氨基-苯甲酸乙酯的工业化生产。

Objective To optimize the synthesis technology of ethyl 3-amino-2-[(2'-cyanobiphenyl-4-yl) methylamino] benzoate. Methods Using ethyl 2-[(2'-cyanobiphenyl-4-yl) methylamino]-3-nitrobenzoate as starting material, hydrazine hydrate as reducing agent, and Pb/C as catalyst, ethyl 3-amino-2-[(2'-cyanobiphenyl-4-yl) methylamino] benzoate was obtained. Results Under the optimum conditions: molar ratio of raw material-reducing agent was 1.92:1, the quantity of catalyst Pb/C was 1.2 g, and at 75 ℃ for 2 h, the yield reached 92.0%. Conclusion The synthesis technology of ethyl 3-amino-2-[(2'-cyanobiphenyl-4-yl) methylamino] benzoate is stable, simple, high yield, and could be applied to industry production.