[关键词]
[摘要]
卵巢上皮性癌占卵巢恶性肿瘤85%~90%,由于缺乏有效的早期诊断和发现的方法,75%的患者就诊时已属晚期。血清学标志物以其检测方便、利于大规模筛查的优势在卵巢上皮性癌的早期诊断中起着重要作用。近几年众多学者对其进行了广泛深入研究,发现许多肿瘤标志物与卵巢上皮性癌密切相关,如CA125、HE4、TGF-β1、β2-MG、YKL-40、lyGDⅠ、hK6、hK10、bcl-2、HMGB1、Notch3、P-选择素和肿瘤自身抗体等。寻找特异度、敏感度高的肿瘤标志物,发展以血清学为基础的筛选方法,对于提高卵巢癌早期诊断水平,改善治疗效果、降低卵巢癌患者的病死率具有重要意义。
[Key word]
[Abstract]
Epithelial ovarian cancer is the most common form of ovarian cancers accounting for 85%—90%. Due to the lack of effective screening strategies and the absence of symptoms in early-stage of disease, 75% of cases have developed to an advanced stage at the time of primary diagnosis. Serological markers are convenient to detect and easy to mass screening as well as play an important role in epithelial oarian cancer early diagnosis. Extensive researches showed that many of the tumor markers are closely related to epithelial ovarian cancer, such as CA125, HE4, TGF-β1, β2-MG, YKL-40, lyGD Ⅰ, hK6, hK10, bcl-2, HMGB1, Notch3, P-choose element, and tumor autoantibody, etc. To look for specific and high sensitivity tumor markers, screening method based on serology could improve ovarian cancer early diagnosis level, promote the treatment effect, and reduce the mortality of patients with ovarian cancer..
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