目的 研究无糖型宁心安神糖浆（SNAS）的镇静、催眠作用。方法 采用自主活动试验、戊巴比妥钠阈上催眠剂量试验、睡眠试验、戊巴比妥钠阈下催眠剂量试验，每个试验均选择ICR小鼠60只，随机分为6组，每组10只，分别为空白对照组，安神补脑液组，蔗糖型宁心安神糖浆组，SNAS高、中、低剂量（100、50、25 mL/kg）组，观察SNAS对小鼠的镇静和催眠作用。结果 SNAS能明显减少小鼠的自主活动次数，增加阈下剂量戊巴比妥钠致小鼠入睡数量，延长小鼠睡眠时间，缩短入睡潜伏期。结论 无糖型宁心安神糖浆具有明显的镇静、催眠作用。

Objective To study the sedative and hypnotic effects of Sugar-free Ningxin Anshen Syrup (SNAS). Methods The effects of SNAS on sedation and hypnotism in mice were observed by spontaneous behavior test, pentobarbital sodium hypnosis test (subthreshold and suprathreshold dosages), and sleeping test, in which 60 ICR mice were randomly divided into six groups such as control, Anshenbunao Syrup, Ningxin Anshen Syrup, and SNAS high-, mid-, and low-dose (100, 50, and 25 mL/kg) groups. Results SNAS could apparently inhibit the spontaneous behavior, increase the number of sleeping mice by pentobarbital sodium (subthreshold dosage), prolong the sleeping time, and shorten the sleeping latent period of mice. Conclusion SNAS has obvious sedative and hypnotic effects.

科技部“十一五”重大新药创制项目（2010ZX09401-402）