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[摘要]
目的 研究欧司哌米芬的合成工艺。方法 以4-羟基二苯甲酮为原料,与2-溴乙醇发生威廉姆斯发应,再与3-氯苯丙酮发生麦克莫里反应,得到终产物欧司哌米芬。结果 本工艺路线所得产品产率为70%,质量分数>99.5%。结论 所得欧司哌米芬的合成工艺稳定,操作简单,适合工业化大生产。
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[Abstract]
Objective To study the synthetic process of ospemifene. Methods Ospemifene was synthesized by the Williamson reaction with 4-hydroxybenzophenone as material base, reacted with 2-bromoethanol, and then by the Mcmurry reaction with 3-chloropropiophenone. Results The yield of ospemifene was 70%, and purity was above 99.5%. Conclusion The synthesis process of ospemifene is stable, simple, and suitable for industrial production.
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