液固压缩技术是利用液体赋形剂溶解难溶性药物，然后用涂层材料吸收后得到固体粉末的一种技术。该技术可有效增加生物药剂学分类系统（BCS）Ⅱ类水难溶性药物溶出速率，通过液固压缩技术制得的粉末具有良好的流动性和可压性，工艺简单、成熟。重点介绍液固压缩技术的理论基础、作用机制和制备方法，并对液固压缩技术在难溶药物固体制剂和缓控释制剂中的应用进行归纳总结。

Liquisolid technology implies that poorly water soluble drugs carried in suitable non-volatile liquid systems, by simple blending with suitable excipients ‘carrier and coating materials’, can be converted into a free flowing and readily compactible powder. It has been proved to be a promising technology to improve the dissolution rate of poorly water soluble drugs. The objective of this article is to introduce the theory, mechanisms, and preparation method of this new technology, and to summarize its application in the poorly water-soluble drug preparation and controlled-release formulation.

国家重点基础研究发展计划项目（2010CB735602）