目的 对胶南市人民医院ICU 97例铜绿假单胞菌感染的分布及耐药性进行分析，为临床合理用药提供依据。方法 通过分析2009年1月—2010年12月ICU发生的97例铜绿假单胞菌感染的临床观察资料，评估感染高危因素；以Kirby-Bauer纸片扩散法药敏实验监测铜绿假单胞菌的抗药性。结果 胶南市人民医院ICU发生的97例铜绿假单胞菌医院感染以下呼吸道感染最为常见，铜绿假单胞菌对抗菌药物具有多重耐药性，以碳青霉烯类-亚胺培南的抗菌活性最好。结论 ICU内应严格执行消毒隔离制度和无菌操作，尽量避免铜绿假单胞菌感染的发生；临床用药时应合理使用抗生素，尽可能减少细菌耐药性的产生。

Objective To analyze the Pseudomonas aeruginosa (Schroeter) Migula distribution and drug resistance in 97 cases in ICU of People’s Hospital of Jiaonan which could provide certain reference for using the drugs reasonably. Methods The clinical data of the 97 cases with Pseudomonas aeruginosa (Schroeter) Migula infection in ICU from January, 2009 to December, 2010 were reviewed to evaluate the risk factors for infection. The Kirby-Bauer paper diffusion method was used to monitor the Pseudomonas aeruginosa (Schroeter) Migula drug resistance. Results Lower respiratory tract infection was most common in the 97 cases with Pseudomonas aeruginosa (Schroeter) Migula infection in ICU. Pseudomonas aeruginosa (Schroeter) Migula had multi-drug resistant to antibacterial agents and the antibacterial activity of carbapenems-imipenem was the best. Conclusion In ICU, strict disinfection and execute aseptic operation are required to avoid the occurrence of Pseudomonas aeruginosa (Schroeter) Migula infection. A reasonable use of antibiotics should be applied in clinical medication to minimize the genetration of bacterial resistance.