目的 检测使用三氧化二砷（As2O3）治疗急性早幼粒细胞性白血病（APL）后患者骨髓和血液中砷的浓度，分析砷暴露及暴露时间对机体的影响。方法 对30名砷暴露患者及28名非砷暴露患者进行调查，对30名暴露者，其中包括砷暴露1年半以上（13人）、一年半以内（17人）以及未暴露组进行调查研究；同时随机抽取7名暴露者，采用氢化物发生原子吸收分光光度法检测骨髓和血液中砷代谢产物，对其骨髓和血液中砷浓度进行对比。结果 7例暴露组患者的骨髓与血液中砷浓度对比，骨髓砷浓度（7.99±0.15）μg/L；血液中的砷浓度（7.98±0.15）μg/L，差异无统计学意义（P＞0.05）；同时对暴露一年半以上，暴露一年半以内及对照组进行单因素分析t检验的方法，其两两之间进行比较发现暴露一年半以上组与暴露一年半以内组差异有统计学意义（P＜0.05），两个暴露组与对照组比较，差异均有统计学意义（P＜0.05）。结论 As2O3治疗ALP，砷可以到达骨髓并进行缓慢代谢，且在骨髓中的代谢与在血液中基本相同，随着暴露时间间隔的延长砷浓度有下降趋势。

Objective To detecte arsenic concentration in the bone marrow and blood after As2O3 used for in the treatment of acute promyelocytic leukemia (APL), and to analyze the effects of arsenic exposure and exposure time on the body. Methods Thirty arsenic exposed patients including arsenic exposure (13) more than a year and a half and those within a year and a half (17) and 28 non-arsenic exposed patients were investigated, investigated 30 exposed persons. Meanwhile, 28 patients with bone marrow and blood arsenic concentration were compared. Seven exposed patients were randomly selected to compare arsenic concentration in the bone marrow and blood by hydride generation atomic absorption spectrophotometry in the detection of bone marrow arsenic metabolites. Results The arsenic concentration of bone marrow was (7.99 ± 0.15)μg/L and that of the blood was (7.98 ± 0.15)μg/L, with no significant difference (P>0.05). At the same time, patients exposed to more than a year and a half, exposure to less than a year and a half, and the control group were compared between any two by univariate analysis, t test method, and the results showed that difference between any two groups were statistically significant (P<0.05). Conclusion When As2O3 are used for APL, arsenic could reach the bone marrow and to slow metabolism; Arsenic metabolisms in the bone marrow and in blood metabolism are basically the same, with the extension of exposure time interval the concentration of arsenic shows a downward trend.