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[摘要]
类风湿性关节炎(rheumatoid arthritis,RA)、节段性肠炎(Crohn′s disease,CD)等疾病具有类似的发病机制。肿瘤坏死因子(tumor necrosis factor,TNF)在这些疾病的发生发展中具有非常重要的作用。TNF分子在细胞因子免疫调节网络中位于中枢环节,是重要的炎症介质,过量的TNF导致炎症的发生。目前上市的TNF抑制剂种类繁多,治疗效果显著。然而随着TNF抑制剂广泛应用,这类药物的安全性逐渐受到重视。本文综述了TNF与疾病关系、上市的TNF蛋白抑制剂分子结构、临床应用等方面,重点关注药物潜在的不良反应,并对近期新型TNF抑制剂的研究开发进行总结。
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[Abstract]
The pathogenesis mechanisms of diseases like rheumatoid arthritis (RA), Crohn’s disease (CD) are quite similar. Tumor necrosis factor (TNF) is likely to be of fundamental importance on the generation and development and plays a key role on the cytokine immune network. High level of TNF could induce inflammation. There are some TNF inhibitors marketed or in research, and both of them had remarkable efficacy. Along with TNF inhibitors being widely used, it’s more important to concern about the safety profiles. Therefore, this article reviews the relationship between TNF and diseases, and five TNF protein inhibitors available through structures and clinical use, keeping eyes on their possible side effect and providing some new TNF inhibitors with bright future.
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