目的 确定川赤芍、赤芍、白芍抑制脂多糖（LPS）诱导大鼠肺泡巨噬细胞NR8383过度激活的“药效成分组”。方法 以川赤芍、赤芍、白芍不同提取物LC-MS图谱峰面积及其抑制LPS诱导的NR8383细胞活力增强为基础，采用偏最小二乘回归法，对LC-MS图谱和抑制细胞增殖的内在联系进行谱效分析。结果 LC-MS图上的X11、X6、X1、X2、X9、X3这6个成分组成的“药效成分组”对川赤芍、赤芍、白芍抑制NR8383细胞增殖药效的贡献较大。结论 “药效成分组”的研究显示，同基源的赤芍、白芍在抑制LPS诱导的NR8383细胞增殖方面具有相同的化学成分（X1、X2、X9、X3），但同时也有某些成分（X11、X6）仅能在赤芍中检测到，这提示不同的化学成分及含量差异可能是造成赤芍、白芍功效不同的物质基础。

Objective To study the “effective components group”of Paeoniae Radix Rubra, Paeoniae Radix Veitchii, and Paeoniae Radix Alba in the inhibiting proliferation of NR8383, which was induced by lipopolysaccharide (LPS). Methods The inherent relationship between LC-MS fingerprint and proliferation inhibition with partial least squares regression were analysed, which were based on LC-MS fingerprint peak areas of all samples and the inhibiting of cell activity increase of NR8383 of Paeoniae Radix Rubra, Paeoniae Radix Veitchii, and Paeoniae Radix Alba. Results Effective components group consists of six peaks X11, X6, X1, X2, X9, and X3 of the fingerprint, which played the most inhabitation of NR8383 proliferation. Conclusion “Effective components group” indicates that Paeoniae Radix Rubra and Paeoniae Radix Alba with the same origin contain the common ingredients (X1, X2, X9, and X3) in the inhibiting proliferation of NR8383. However, X11 and X16 only can be detected in Paeoniae Radix Rubra, which can be considered as the different material basis in efficacy between Paeoniae Radix Rubra and Paeoniae Radix Alba.