心脑血管疾病严重威胁人类健康，抗血小板治疗已经被证明可以有效预防和改善心脑血管疾病。噻吩并吡啶类药物是以二磷酸腺苷受体为靶点的一类抗血小板药物，包括噻氯匹定、氯吡格雷和普拉格雷，是目前临床上应用最为广泛、有效的抗血小板聚集、抗血栓药物，极大地改善了全球心脑血管患者的健康状况。概括介绍噻吩并吡啶类药物的代谢与起效模式、作用机制、临床应用及药物相互作用等方面的研究进展。

Cardiovascular and cerebrovascular diseases have become the number one killer which could cause death. Antiplatelet therapy has been shown to be effective to do some prevention and improvement. Thienopyridines, including ticlopidine, clopidogrel, and prasugrel, which are a class of drugs targeting at ADP receptor, have been widely used in clinical practice to greatly improve the health of cardiovascular and cerebrovascular diseases status around the world. The objective of this article is to summarize the research progress in drug metabolism, mode of actions, clinical practice, and the drug-drug interactions of thienopyridines in brief.

国家重大新药创制专项（2011ZX09401-009）