目的 建立复方洋参归地丸的质量标准。方法 采用薄层色谱法对制剂中当归、川芎、何首乌、石菖蒲、黄芪进行定性鉴别；采用高效液相色谱–蒸发光散射（HPLC-ELSD）法测定人参皂苷Rb1。结果 薄层色谱鉴别的色谱斑点清晰，阴性对照无干扰。人参皂苷Rb1在1.832～18.320 μg呈良好的线性关系，平均回收率为100.06%，RSD为1.69%（n=6）。结论 所建立的方法简便可行，专属性强，重现性好，可用于复方洋参归地丸的质量控制。

Objective To establish the quality control methods for Compound Yangshen Guidi Pills. Methods The method of TLC was used to qualitatively identify Angelicae Sinensis Radix, Chuanxiong Rhizoma, Polygoni Multiflori Radix , Acori Tatarinowii Rhizoma, and Astragali Radix. The content of ginsenoside Rb1 was determined by HPLC-ELSD. Results All herbal drugs in Compound Yangshen Guidi Pills were well identified by TLC and the spots were clear and without interference. The linear range of ginsenoside Rb1 was 1.832—18.320 μg, with the average recovery of 100.06%, and the RSD of 1.69% (n=6). Conclusion The established method is simple, feasible, and can be used for the quality control of Compound Yangshen Guidi Pills.