目的 对五味止痛片的处方进行优化。方法 以颗粒的休止角、吸湿率、片芯硬度为指标，采用单因素试验优选五味止痛片的最佳处方。结果 优选出最佳处方：以乳糖为填充剂，崩解剂乳糖、磷酸氢钙、预胶化淀粉的比例为2∶2∶1.5，使用92%乙醇作为湿润剂，用量约为粉末的20%。结论 制得的五味止痛片表面光洁度、硬度符合薄膜包衣片工艺要求，工艺简便可行，适宜工业化生产。

Objective To optimize the formula of Wuwei Zhitong Tablets Methods The best formula was optimized by single-factor test with repose angle, moisture absorption rate of the granula, and the hardness of tablets as indexes. Results The optimal formula was filling agent by using lactose, and the ratio of lactose, CaHPO4 and amylum pregelatinisatum as disintegrant with 2∶2∶1.5, the wetting agent was 92% ethanol with the 20% of total powder. Conclusion The tablets are smooth and glossy, and have optimum hardness in accordance with the requirement. The process is simple and valuable for industrial production.

国家重大新药创制专项（2009ZX09103-443）