[关键词]
[摘要]
目的 合成拉喹莫德并对工艺进行研究。方法 以2-氨基-6-氯苯甲酸为起始原料,经成环反应、甲基化反应、缩合反应、水解反应等合成了拉喹莫德。结果 合成的拉喹莫德总收率为71.8%。结论 工艺改进后,简化了操作过程,提高了拉喹莫德的收率。
[Key word]
[Abstract]
Objective To synthesize Laquinimod and improve the synthetic technology. Methods Taking 2-amino-6- chlorobenzoic acid as the raw material, Laquinimod was obtained after a series of chemical reactions including cyclization, methylation, condensation, and hydrolization reaction. Results Laquinimod was prepared with an overall yield rate of 71.8%. Conclusion The improved procedure could simplify the synthesis and increase the yield of Laquinimod.
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[基金项目]
科技部“十二五”重大新药创制(2011ZX09102-007-03);广东省教育厅高层次人才资助项目;广东省科技计划项目(2010B030700044,2011A030100013)