目的 合成拉喹莫德并对工艺进行研究。方法 以2-氨基-6-氯苯甲酸为起始原料，经成环反应、甲基化反应、缩合反应、水解反应等合成了拉喹莫德。结果 合成的拉喹莫德总收率为71.8%。结论 工艺改进后，简化了操作过程，提高了拉喹莫德的收率。

Objective To synthesize Laquinimod and improve the synthetic technology. Methods Taking 2-amino-6- chlorobenzoic acid as the raw material, Laquinimod was obtained after a series of chemical reactions including cyclization, methylation, condensation, and hydrolization reaction. Results Laquinimod was prepared with an overall yield rate of 71.8%. Conclusion The improved procedure could simplify the synthesis and increase the yield of Laquinimod.

科技部“十二五”重大新药创制（2011ZX09102-007-03）；广东省教育厅高层次人才资助项目；广东省科技计划项目（2010B030700044，2011A030100013）