目的 观察过山蕨总黄酮对血栓闭塞性脉管炎模型大鼠的改善作用。方法 大鼠股动脉注射月桂酸制备血栓闭塞性脉管炎，造模后肉眼观察病变肢情况并评分，按评分结果将大鼠随机分为模型组，对照组，过山蕨总黄酮高、中、低剂量（7.2、3.6、1.8 mg/kg）组和脉管复康片（648 mg/kg）阳性对照组，每组10只，给药组于造模3 d后每天ig给药1次，连续7 d。观察大鼠体征、血栓病理切片、血液流变学指标。结果 过山蕨7.2 mg/kg可显著改善血栓性闭塞性脉管炎模型大鼠的症状。

Objective To observe the improving effect of total flavonoids from Camptosorus sibiricus on rats with thromboangiitis obliterans. Methods The thromboangiitis obliterans of rats was made by administration lauric acid into femoral artery. After the models were made, the limb lesions were observed and scored, by which the rats were divided into model group, control group, administration group (7.2, 3.6, and 1.8 mg/kg), and Maiguan Fukang Tablet (648 mg/kg) as positive control group with ten in each group, respectively. After the models were made for 3 d, the successive ig administration was given once a day for 7 d. The physical signs, pathological sections, and hemorheological indexes were investigated. Results The significant improving effect of total flavonoids from C. sibiricus on model rats with thromboangiitis obliterans was observed in the high dose (7.2g/kg) group. Conclusion The treatment of the total flavonoids from C. sibiricus on rats with thromboangiitis obliterans may be related to the effect of blocking α-receptor, exciting β-receptor, antinorepinephrine, and inhibiting the platelet aggregation induced by ADP.

“重大新药创制”科技重大专项（2009ZX09102）；辽宁省博士科研启动基金资助项目（20091079）