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目的 对(2S,3R)-1-二甲氨基-3-(3-甲氧基苯基)-2-甲基戊-3-醇合成工艺进行研究。方法 以3-戊酮为起始原料,经Mannich反应、手性拆分、Grignard反应等步骤合成(2S,3R)-1-二甲氨基-3-(3-甲氧基苯基)-2-甲基戊-3-醇,并对化学拆分进行工艺优化。结果 合成(2S,3R)-1-二甲氨基-3-(3-甲氧基苯基)-2-甲基戊-3-醇,总收率为30.6%。结论 工艺改进后提高了目标产物的收率,同时也减少了原料的浪费。
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[Abstract]
Objective To study the synthetic technology of (2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol. Methods 3-Pentanone was taken as the starting material, (2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol was obtained after a series of chemical reactions including Mannich reaction, resolution, Grignard reaction, and so on. At the same time, the procedure of chiral resolution was optimized. Results (2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol was synthesized with an overall yield of 30.6%. Conclusion The improved procedure can increase the yield of product and reduce the waste of raw material.
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