目的 研究美洲大蠊醇提物对四氯化碳（CCl4）和刀豆蛋白A（Con A）所致小鼠肝损伤的保护作用。方法 采用ip 0.1% CCl4以及尾iv 20 mg/kg Con A造成小鼠急性肝损伤，检测血清中ALT、AST和肝组织中SOD、MDA的水平。将肝大叶HE染色，观察美洲大蠊醇提物对小鼠肝脏组织病理学的影响。结果 美洲大蠊醇提物能明显降低CCl4所致的肝损伤小鼠肝脏、脾脏指数的升高，降低肝损伤小鼠血清中ALT、AST的升高（P＜0.05），降低小鼠肝组织中MDA水平、升高SOD（P＜0.05）；肝脏组织病理学观察可见，美洲大蠊醇提物能够减轻炎性因子的浸润，减轻肝细胞的水肿程度，减少肝细胞坏死，促进肝细胞的再生。结论 美洲大蠊醇提物具有显著的抗CCl4和Con A所致肝损伤的作用。

Objective To study the protective effect of Periplaneta americana extract against liver injury in mice induced by carbon tetrachloride (CCl4) and concanavalin A (Con A). Methods Acute liver injury of mice was induced by ip injection 0.1% CCl4 or iv injection 20 mg/kg Con A. Contents of ALT, AST, SOD, and MDA were determined by UV spectrophotometer. HE staining was used to test the pathology of liver. Results P. americana extract could obviously decrease liver and spleen index of liver-injured mice caused by CCl4 and Con A, and remarkably resist the increase of ALT, AST in mice serum, MDA in hepatic tissue (P<0.05), and the decrease of SOD in hepatic tissue (P<0.05). According to the liver tissue histopathology, P. americana extract could alleviate infiltrating of the inflammatory factor, reduce the degree of liver cells′ edema and necrosis, and promote the liver cells′ regeneration.