[关键词]
[摘要]
DLL4-Notch信号传递在人体组织的发育过程和细胞间通讯中发挥关键作用,其中包括调控细胞命运,调节细胞迁移、分化和增殖。最近的研究已经证实,在多种肿瘤细胞系中存在Notch基因的异常表达,且DLL4-Notch信号与肿瘤细胞的生长调控密切相关,因此该信号通路成为肿瘤诊断与治疗的新靶点。简要介绍DLL4-Notch信号传递系统的组成,以及国外关于DLL4-Notch信号传递途径在抗肿瘤、调节血管生成与调节淋巴网络形成等方面最新的研究进展。
[Key word]
[Abstract]
The DLL4-Notch signal transduction plays a key role in cell development and cell-cell communication in vertebrates and invertebrates, including the regulations of cell fate, migration, differentiation, and proliferation. Recent studies have shown that in many tumor cell lines, Notch genes were abnormally expressed and DLL4-Notch signaling was correlated with the regulation of tumor cells, so this pathway could provide potential new targets for the diagnosis and therapy of tumor. The latest researches about the DLL4-Notch pathway in antitumor, angiogenesis, and lymphopoiesis abroad in recent years have been overviewed in this paper.
[中图分类号]
[基金项目]
广东省科技计划项目(2010B030700044);广东省高等学校高层次人才项目