摘 要: 目的 研究丁酸氯维地平主要杂质的结构和产生的原因。方法 以3-羟基丙腈为起始原料，经过酯化、缩合、水解、取代反应制备目标化合物。用液-质联用法推导该杂质结构。结果 按照设计路线，合成出丁酸氯维地平主要杂质。结论 经1H-NMR确证目标化合物结构为4-(2,3-二氯苯基)-1-4-二氢-2-6-二甲基-3,5-吡啶二羧酸双(1-氧代丁氧基)甲酯。

Abstract: Objective To identify the structure and cause for product of the main impurity of cleviprex butyrate. Methods LC-MS was used to speculate the main impurity. The target compound was synthesized via esterification, condensation, hydrolization substitution, using 3-hydroxypropionitrile as starting material. Rusults The main impurity of cleviprex butyrate was synthesized by the design route. Conclusion 1H-NMR is used to confirm the target compound, the structure is bis (butyryloxymethyl) 4-(2,3-dichloro-phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.