摘 要：目的 研究适合工业化生产的丁酸氯维地平合成方法。方法 采用2,3-二氯苯甲醛、β-氨基巴豆酸甲酯与乙酰乙酸乙酯环化缩合，选择性水解得到4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二羧酸单甲酯钾盐，再同丁酸氯甲酯反应得到丁酸氯维地平。结果 该合成工艺的丁酸氯维地平总收率为48%。结论 该工艺稳定，操作简单，适合工业化生产丁酸氯维地平。

Abstract: Objective To investigate the industrialization method for clevidipine butyrate．Methods Clevidipine butyrate was synthesized after several processes，including cyclocondation of 2,3-dichlorobenzalde- hyde，methyl β-aminobutenate and ethyl acetoacetate，selective hydrolysis through which 4-(2,3-dichloro- pheny1)-1,4-dihydro-2,6-dimethy-3,5-pyridinedicarboxylic acid monomethyl ester potassium salt was obtained，and reaction with chloromethy butyrate．Results The total yeild rate of clevidipine butyrate was 48%．Conclusion This method was simple and reproducible，and this synthesis route is suitable for the commercial production of clevidipine butyrate．