摘 要：目的 对美愈伪麻的低共熔现象进行研究，考察了不同制备工艺对美愈伪麻低共熔物形成及压片的影响。方法 通过绘制二元和三元相图确定愈创木酚甘油醚、盐酸伪麻黄碱和氢溴酸右美沙芬2组分间的最低共熔点及3组分间的低共熔温度。结果 愈创木酚甘油醚、盐酸伪麻黄碱和氢溴酸右美沙芬3组分间存在低共熔现象，3组分的低共熔温度为62.6 ℃。结论 通过对美愈伪麻低共熔现象的研究，为设计其合理制备工艺提供理论依据。

Abstract: Objective To study the eutectic phenomenon of guaifenesin，pseudoephedrine hydrochloride and dextromethorphan hydrobromide in compound preparation and to investigate the effect of preparation process on eutectics and tablet pressing．Methods The eutetic melting point between two-component mixture and the eutectic temperature of the compound were determined by the phase diagram of binary and ternary systems．Results There existed eutectic phenomenon among guaifenesin，pseudoephedrine hydrochloride and dextromethorphan hydrobromide．The eutectic temperature of the three-component mixture was 62.6 ℃．Conclusion This study of the eutectic phenomenon can provide certain reference to design a suitable craft to prepare dextromethorphan Hydrobromide，guaifenesin and pseudoephedrine hydrochloride pharmaceutics．

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