摘 要：创新药物研究和开发的理论、方法和关键技术随着生物技术的发展而发展，我国创新药物研究获得前所未有的机遇，也面临着重大挑战。在“关键路径研究”中，实施转换医学研究或转换研究不但影响医药企业的新产品研发过程，也会对研发机制产生深远的影响。转换医学为提高研究开发效率提供了机遇和挑战，在新药发现、研究开发、临床前和临床评价研究的各个阶段，应用转换研究模式，科学地利用获得的有用信息，把握转换研究与新药研发三要素，定能降低研发成本和缩短研究时间，提高研发效率和速度。笔者主要论述转换医学的发展、国际动态、我国创新药物研究所面临的机遇和挑战等方面的内容。

Abstract：Current innovative drug research and development of the theory，methods，and key technology is the rapid emergence of China will be conducive to the research of innovative medicines to improve the strength and the overall level．For the establishment of China's independent innovation system，so we face major challenges in innovative drug research in China to reach close to the country's overall level．Translational medicines proves the opportunities and challenges in drug discovery，research and development（R&D），preclinical and clinical evaluation of the various stages of conversion of application mode，use the three elements of druggablity to evaluate of new drugs. This review will convert the development of translational medicine，the international statues，and the opportunities and challenges in application to R&D of new drugs．