目的 探讨E-钙粘素在子宫内膜异位症的异常表达及意义。方法 应用免疫组织化学及图像分析方法比较E-钙粘素在正常子宫内膜、内膜异位症在位及异位内膜中的量。结果 正常子宫内膜和内膜异位症在位内膜腺上皮E-钙粘素的表达无明显的周期性变化。在整个月经周期中，内膜异位症在位内膜腺上皮E-钙粘素的表达显著低于同期正常子宫内膜。卵巢子宫内膜异位囊肿中异位内膜腺上皮E-钙粘素的表达显著低于同组患者的在位内膜。结论 子宫内膜异位症在位和异位内膜腺上皮E-钙粘素的表达降低与内膜异位症的发病密切相关。

Objective To study the role of E-cadherin in the pathogenesis of endometriosis.Methods E-cadherin in normal endometria, eutopic and ectopic endometria from patients with ovarian endometriosis were examined by means of immunohistochemical study and image analysis.Results The expression of E-cadherin was detected in eutopic endometrial epithelial cells of normal cycling women and patients with endometriosis, and it showed no variation throughout the menstrual cycle. When compared with that of normal endometrium in the same phase, the expression of E-cadherin in eutopic endometrial epithelial cells of endometriosis was significantly lower. The epithelial cells of endometriotic endometrium showe d a significant lower E-cadherin expression than eutopic endometrium of endomet riotic patients did.Conclusion The abnormal expression of Ecadherin in eutopic and ectopic endometrial epithelial cells of endometriosis might play a significant role in the pathogenesis of endometriosis.

广东省中医药管理局建设中医药强省科研项目(2008095)