目的 采用均匀设计法及相关分析对复方甘草锌与氨来呫诺口腔复合膜的处方进行优选。方法 不同配比的聚乙烯醇（PVA）、羟丙甲基纤维素（HPMC）、丙二醇为成膜材料，以膜剂的柔软性、均匀性、光滑性、透明性作为考察指标，采用均匀设计法及相关分析筛选最优处方并进行透皮吸收试验。结果 最佳成膜材料处方为：PVA 6.5 g，HPMC 0.1 g，丙二醇6.0 g。透皮实验结果表明，甘草锌和氨来呫诺都滞留在皮内，可以更好地促进溃疡面愈合。结论>/b> 采用上述配比的处方可制备出优良的口腔溃疡复合膜，满足缓释、安全的要求。

Objective To optimize the prescription of compound licorzinc and Amlexanox oral complex pellicle and improve the quality control by using uniform design and correlation analysis.Methods Different ratio of PVA，HPMC and propylene glycol were used as the composite materials of the pellicleSoftness，uniformity， smoothness， and transparency of the pellicle were regarded as parameters. Uniform design and correlation analysis were adopted for the formulation optimization. Cutaneous absorption test was carried out.Results The optimal formulation of filmforming materials was PVA： 6.5 g，HPMC：0.1 g，propylene glycol：6.0 g. The experimental results showed that licorzinc and Amlexanox remained in skin and promoted ulcer healing.Conclusion Preparation of the above prescription can be excellent oral complex pellicle to meet the requirements of slow release and safety.