目的 探讨新癀片中的中药组分对化学药成分吲哚美辛的减毒作用。方法 采用急性毒性实验。给ICR小鼠分别ig不同剂量的新癀片、化学药成分吲哚美辛，记录各组小鼠的死亡数、毒性症状，用Bliss法分别计算LD50。同时另设新癀片中药组分组，确定其最大给药量，并观察毒性反应。结果 新癀片中药组分对小鼠的1日最大给药量为18.2 g/kg。吲哚美辛的LD50为18.31 mg/kg，新癀片的LD50为1 217.83 mg/kg，由于吲哚美辛在新癀片中的质量分数为2.478%，因此折算成新癀片中吲哚美辛的LD50为30.16 mg/kg。结论 新癀片中中药组分对吲哚美辛具有减毒作用。

Objective To study the attenuation effect of Chinese medicinal components in Xinhuang Tablets on indomethacin.Methods Various doses of Xinhuang Tablets and indomethacin were given to ICR mice by ig administrationClinical signs and death were recorded LD50 was computed by Bliss method Meanwhile the maximal administration dose of Chinese medicinal components in Xinhuang Tablets was included，and their acute toxic reactions were observed. Results There were no toxic effects observed when a 18.2 g/kg dose of Chinese medicinal components in Xinhuang Tablets (the maximal acceptable dose) was given to mice. The LD50 of indomethacin in mice was 18.31 mg/kg. The LD50 of Xinhuang Tablets in mice was 1 217.83 mg/kg. As the content of indomethacin in Xinhuang Tablets was 2.478%，the equivalent LD50 of indomethacin in mice was 30.16 mg/kg.Conclusion Chinese medicinal components in Xinhuang Tablets can reduce the toxicity of indomethacin.

国家科技支撑计划地方重大专项(2007BAQ00162）