目的Ziziphora clinopodioides不同提取物对大鼠急性心肌缺血、对乳鼠心肌细胞缺氧复氧损伤的影响。方法 通过体内注射垂体后叶素造成大鼠急性心肌缺血模型，观察急性心肌缺血大鼠Ⅱ导联心电图J点的变化，以及试药对超氧化物歧化酶（SOD）、乳酸脱氢酶(LDH)、丙二醛(MDA)的影响。体外培养原代SD乳鼠心肌细胞，建立心肌细胞缺氧复氧损伤模型，用MTT法测定药物对心肌细胞存活率的影响，测定给药后MDA的变化。 结果 芳香新塔花石油醚部位和氯仿部位0.3 g/kg显著抑制注射垂体后叶素所致心电图J点升高，对心率、SOD、LDH、MDA的影响不显著；乙醇提取物和氯仿部位能明显降低缺氧-复氧模型下心肌细胞培养液中的MDA浓度。 结论芳香新塔花具有潜在的心肌缺血保护作。

Objective To study the protective effects of ethanol extract and isolated fraction from Ziziphoraclinopodioides Lam. on acute myocardial ischemia of rats and neonatal rat cardiomyocytes damaged by hypoxia/reoxygenation stress. Methods Acute myocardial ischemia of rats was induced by injection of pituitrin. Electrocardiogram (ECG) was recorded， and the levels of lactate dehydrogenase (LDH)，super-oxide dismutase (SOD) and the malondialdehyde (MDA) in medium were also tested. The neonatal rat cardiomyocytes were isolated and cultured in vitro to establish hypoxia/reoxygenation injury model The viability of cardiomyocytes was measured by MTT method.Change of MDA content in medium were also determined.Results Petroleum ether fraction and chloroform fraction (0.3 g/kg) remarkably inhibited the raise of J point caused by pituitrin， and significantly decreased MDA content in the model of hypoxia/reoxygenation injury. Conclusion Z. clinopodioides has a potential protective effects on acute myocardial ischemia and neonatal cardiomyocyte damage induced by hypoxiao/reoxygenation stress.

新疆维吾尔族自治区科技基础条件平台建设项目（PT0708）；新疆维吾尔药实验室课题（xjys0207-2008-03)