目的 观察叶酸联合维生素B₁₂干预治疗糖尿病肾病的临床疗效。方法 90例糖尿病肾病患者随机分为治疗组(45例)和对照组(45例)，对照组给予控制血糖及相应对症治疗，治疗组在采用对照组治疗方法的基础上加用叶酸和维生素B₁₂，两组疗程均为14 d。比较两组病人的肝肾功能，24 h尿中微量白蛋白(udnary albumin)、叶酸、维生素B₁₂、同型半胱氨酸(Hcy)等水平。结果 与对照组比较，治疗组病人24 h尿蛋白的量、Hcy明显降低(P＜0.05)，其他指标两组间差异无统计学意义。结论 叶酸联合维生素B₁₂干预治疗能明显降低糖尿病肾病患者24 h尿微量白蛋白和Hcy水平，对糖尿病肾病患者的肾脏有保护作用。

Objective To observe the clinical efficacy of folic acid tablets in combination with Vitamin B tablets for diabetic nephropathy. Methods A total of 90 patients with diabetic nephropathy were randomly divided into two groups: control group (45 cases) and treatment group (45 cases). Patients in the control group received blood sugar control and other therapies according to the symptoms. Patients in the treatment group received folic acid tablets and Vitamin B₁₂ on the basis of therapies described in the control group. Both the treatment courses in the two groups were 14 days. The indices of the two groups were compared, including liver function, kindney function, 24 h urinary microalbumin, folic acid, Vitamin B₁₂ and homocysteine Hcy). Results Compared with that of control group, Patients in the treatment group had a lower 24 h urinary microalbumin and homocysteine (P＜0.05).There was no statistic significance in other comparisons between the two groups. Conclusion Folic acid tablets in combination with Vitamin B₁₂ tablets are safe and effective to lower the 24 h urinary microalbumin and Hcy of patients with diabetic nephropathy, and can protect the kidney of patients.