肿柄菊来源于菊科肿柄菊属植物，主要化学成分是倍半萜内酯，还含有黄酮、色原酮、色原烯以及二萜、蒽醌和神经酰胺等。肿柄菊的药理作用主要有抗炎、抗疟、抗肿瘤、降血糖以及其他一些活性。对近年来肿柄菊的倍半萜、色原烯等化学成分以及抗疟、抗炎、降血糖等药理活性做简要综述。

Most antipyretic-analgesic and anti-inflammatroy drugs are COX-2 inhibitors. There is a huge market for antipyretic-analgesic and anti-inflammatory drugs. Although these drugs have some toxic and side effects, there is no better substitute for them. After the discovery of mPGES-1, rescarchers pay much attention to this novel target, and have done many studies on biochemical and pathophysiological as pects of mPGES-1. Nevertheless the strdies on pharmaceutical aspect of mPGES-1 are still in the intitial stage. It is promising to developing new mPGES-1 inhibitors.

上海市科学技术委员会资助项目（08DZ1971503）；国家自然科学基金项目（20872177）