目的 建立心肌梗死超急性期心肌缺血模型。方法 用清醒比格犬与遥控实时检测技术，测定冠脉前降支气囊压迫狭窄后心肌缺血的电生理特征与血压变化。结果 随冠脉流量的下降，ST段电压先出现压低(压低相)，再呈现电压幅度升高(缓台相、急抬相），并伴随T波、R波电压不同程度地升高；ST段、T波、R波电压在不同时相变化率不同，提示其敏感性不同，且T波、R波电压在不同时相与ST段电压变化相关性不同；Q波电压与时程，以及心率(HR)、血压(BP)无明显变化。结论 采用清醒比格犬与遥控实时检测技术建立的心肌梗死超急性期缺血模型，其特点与临床一致，方法科学、可靠。

Objective To establish the ischemia model for hyperacute-phase myocardial infarction. Methods Conscious Beagle dogs were chosen as the experimental animals. Remote real-time detection technology was applied to measure the electrophysiological characteristics of myocardial ischemia and changes in blood pressure after anterior descending coronary artery stenosis with balloon tamponade. Results With the decline in coronary blood flow, voltage of ST segment was depressed firstly (depressed stage),and then elevated (slow lift stage, acute lift stage), accompanied with T and R wave voltage increasing in different degrees. The variation rates of ST, T and R-wave voltage were various in different stage, suggesting a characteristic sensitivity of electrophysiological wave. In addition, there was diference in the relevance of change between T or R-wave and ST segment in different stage. However, in this model, there was no significant change in Q-wave voltage, heart rate and blood pressure. Conclusion It is scientific and reliable to use conscious Beagle dogs and remote real-time detection technology to establish the ischemia model for hyperacute-phase myocardial infarction.

国家科技支撑计划项目(NO.2007BAI41B02)；系列化、国际化的国家生物医药国际创新园新药研发综合性大平台建设项目(2009ZX09301-008)