目的 探讨液基薄层细胞制片技术在肺肿瘤诊断中的应用价值。方法 选取纤维支气管镜刷检细胞学诊断 1 580 例肺肿瘤患者，同时采用常规刷片、液基薄层细胞制片进行细胞学诊断，并随诊患者的临床及病理资料。结果 1 580 例标本中给组织病理诊断肺部恶性肿瘤 864 例，常规刷片诊断 747 例，液基薄层细胞制片诊断 795 例，液基薄层细胞学、常规刷片诊断敏感度分别为 92%、86%，特异性分别为 95.1%、84%。液基薄层细胞学、常规刷片分型诊断符合率分别为：鳞癌 96.2%、93.5%，腺癌 94.3%、87%，小细胞癌 98%、90%。结论 纤维支气管镜液基薄层细胞技术在肺肿瘤诊断中具有较高的特异性及分型诊断符合率。

Objective To evaluate the application of ThinPrep technology in the diagnosis of lung cancers. Methods 1 580 patients who underwent ThinPrep bronchial brushing cytology and conventional preparation examination were collected and the related clinical and pathological data were analyzed. ResultsThere were 864 malignant patients with histopathological diagnosis, and 747 malignant patients with conventional preparation diagnosis of 1 580 patients. The sensitivity of ThinPrep bronchial brushing and conventional preparation cytology were 92% and 86%, The specificity were 95.1% and 84%, The accordant rate of cytology in subclassification was 96.2% and 93.5% in squamous cell carcinoma, 94.3% and 87% in adenocarcinoma and 98% and 90% in small cell lung cancer. Respectively. Conclusion ThinPrep bronchial brushing cytology has good sensitivity and specificity in the typing and diagnosis of lung cancer.