[关键词]
[摘要]
目的 观察芹菜根提取物对四氯化碳(CCI4)所致大鼠急性肝损伤的作用.方法 50只Wistar大鼠随机分为5组:阴性对照组、模型对照组、阳性对照组、芹菜根高、低剂量给药组,高、低剂量组分别灌胃3、1.5 g/kg芹菜根提取物,阳性对照组灌胃200mg/kg联苯双酯滴丸,阴性对照组及模型对照组以等体积生理盐水灌胃,共7 d.第7天,模型对照组、阳性对照组和各给药组ip CCl4溶液1 mL/kg,正常组注射等体积生理盐水.测定各组大鼠血清天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT),肝组织中超氧化物歧化酶(SOD)活性和丙二醛(MDA)的量,并观察肝组织病理改变.结果 芹菜根提取物能显著降低CCI4所致大鼠血清AST、ALT量的升高及肝组织中MDA的量,增强肝组织中SOD活性.结论 芹菜根提取物对CCI4所致的大鼠急性肝损伤具有一定的保护作用.
[Key word]
[Abstract]
Objective To observe the effect of celery root on acute liver injury induced by CCl4in rats.Methods Fifty rats were randomly divided into normal control group,model control group,position control group,high-dosage and low-dosage celery root extract group.The rats in all groups were administered for 7 d.The high-dosage and low-dosage celery root extract groups were pretreated intragastrically with 3,1.5 g/kg celery root extract,and position control group were pretreated intragastrically bifendate pills 200 m...
[中图分类号]
R285.5
[基金项目]
新疆高等学校科研项目 ?
