目的观察白英消疹止痒凝胶(以下简称"白英凝胶")的药理作用。方法给大鼠注射组织胺和5-羟基色胺0.1mL致炎,观察白英凝胶对血管通透性的影响;观察该凝胶对0.01%磷酸组胺对豚鼠致痒阈的影响;采用二甲苯致炎法,观察不同药物对小鼠耳廓肿胀的影响;取金葡菌、大肠杆菌、绿脓杆菌、沙门氏菌和白色念珠菌等,分别加入不同浓度的白英凝胶溶液,观察其抑菌浓度。结果白英凝胶明显缩小大鼠的皮肤色斑面积和皮肤厚度,降低皮肤的吸光度,改善皮肤血管的通透性;明显提高豚鼠对磷酸组织胺的致痒阈及小鼠耳廓肿胀抑制率。白英凝胶还表现出一定的抑菌作用,对金葡菌、大肠杆菌、沙门氏菌和白色念珠菌的MIC为100mg/mL,对绿脓杆菌的MIC为50mg/mL。结论白英凝胶具有止痒、抗炎和抗菌等药理作用,适用于治疗慢性湿疹。

Objective To observe the pharmacological actions of Baiying Xiaozhen Zhiyang Gel(hereinafter called "Baiying Gel").Methods The influence of Baiying Gel on vascular permeability was observed in rats with inflammation induced by injection of 0.1 mL of histamine and serotonin,its influence on 0.01% of histamine phosphate-induced itching threshold in claws of guinea pigs;the influences of various drugs on auricular swelling induced by dimethyl benzene were observed in mice.The bacteria-inhibitory concentrations of Baiying Gel were obtained in experiment with various concentrations of the Gel containing Staphylococcus aureaus,Escherichia coli,Pseudomonas aeruginosa,Salmonellae or Candiada albicans.Results Baiying Gel obviously reduced pigmentation area,thickness and optical density and improved vascular permeability of rats'skin,marked increased histamine phosphate-induced itching threshold in guinea pigs and auricular swelling-suppressive rate in mice(P<0.05).In addition,Baiying Gel showed definite bacteria-inhibitory actions,with MIC of 100 mg/mL against Staphylococcus aureaus,Escherichia coli,Salmonellae and Candiada albicans,and with MIC of 50 mg/mL against Pseudomonas aeruginosa.Conclusion Baiying Gel has notable itching-relieving,anti-inflammatory and anti-bacterial actions,and it is suitable for the treatment of chronic eczema.

R284.1

国家科技型中小企业技术创新基金