[关键词]
[摘要]
中药创新是中药现代化、国际化的灵魂。如何借助现代生命科学和医药学最新理论技术实现创新中药研发是中药研究中亟待解决的关键问题。基于我国近百年的中药现代研究的历史和经验,借鉴西方天然药物研发的思路,以中药创新研究中的几个成功的先例,总结和归纳了创新中药研究的6种主要模式:青蒿素模式、培养基模式、GBE761-Veregen模式、PHY906模式、复方丹参滴丸模式、PC-SPES模式,评述了各个模式在创新中药研究中的应用、特点、优缺点等,并对其发展前景进行了展望。
[Key word]
[Abstract]
The innovation of Chinese materia medica (CMM) is the soul of traditional Chinese medicine (TCM) modernization and internationalization. The application of modern theories and techniques in life sciences and medicine to innovative CMM research remains to be an urgent issue to be solved in TCM research area. This paper summarizes and generalizes six main R&D models for CMM innovation according to the nearly one century of history and experiences accumulated in TCM research in China and referencing to the idea and philosophy of natural product study in Western countries as well. The nomenclature of these models is based on several successful drug discovery examples in TCM, such as the artemisinin model, the culture medium model, the GBE761-Veregen model, the PHY906 model, the Compound Danshen Dripping Pills model, and the PC-SPES model. The application, characteristics, advantages, disadvantages, and the development prospect of each model in TCM R&D have been reviewed.
[中图分类号]
[基金项目]
澳门大学研究基金资助(SRG013-ICMS11-CXP)