摘 要：目的 建立蜣螂有效部位的毛细管电泳（CE）指纹图谱，探讨利用总量统计矩法分析指纹图谱的可行性。方法 采 用毛细管区带电泳法（CZE），以弹性石英毛细管柱（60 cm×75 μm）为分离通道，75 mmol/L 硼砂溶液（pH 9.8）作缓冲液， 运行电压＋20 kV，检测波长200 nm，指纹图谱的评价采用药典委员会相似度分析软件与总量统计矩法。结果 建立了蜣螂 有效部位的CE 指纹图谱，药典委员会的相似度软件与总量统计矩法计算的相似度基本一致，显示蜣螂有效部位批间差异小。 结论 本CE 指纹图谱准确简便，重现性好，可作为蜣螂提取物的质量控制方法，而总量统计矩法可以作为指纹图谱的分析 方法。

Abstract: Objective To establish capillary electrophoresis (CE) fingerprint of effective fraction of Catharsius molossus Linnaeus and explore the feasibility of fingerprint evaluation by total quantum statistical moment method. Methods Capillary zone electrophoresis (CZE) was used. Electrophoretic conditions were as follows: fused silica capillary column (60 cm × 75 μm), 75 mmol/L borate solution as the running buffer (pH 9.8), applied voltage of + 20 kV, detection wavelength of 200 nm. Fingerprint was evaluated by SFDA’s similarity analysis software and total quantum statistical moment method. Results The main components in Catharsius molossus Linnaeus were separated. There were good similarities in six batches by SFDA’s similarity analysis software and total quantum statistical moment method. Conclusion The method was acurate, simple and had good reproducibility. It can be used for the quality control of effective fraction from Catharsius molossus Linnaeus. The total quantum statistical moment method can be used to analyze fingerprint.