摘 要：目的 研究天麻药材-饮片-浸膏-配方颗粒这一制备过程中气味的变化与相关性，尝试引入新的制剂工艺整体评价指 标，探讨符合中医药整体观的中药配方颗粒制备工艺。方法 利用电子鼻技术采集各样品的气味数据，通过主成分分析 （PCA）、判别因子分析（DFA）和统计质量控制分析（SQCA）等统计学方法对特征数据进行分析。结果 天麻药材-饮片- 浸膏这一制备过程中，天麻气味损失较小；而浸膏-配方颗粒这一过程中气味损失较大，提示按现有化学药模式评价中药配 方颗粒工艺虽然可行，但这与符合中医药整体观的气味指标评价结果有差异。结论 电子鼻技术可用于天麻样品（不同的形 式）气味信息数据的采集，通过不同的模型进行数据分析后，可从不同天麻样品的气味之间找出差异与相关性，气味指标可 作为天麻配方颗粒制剂工艺的整体评价指标。

Abstract: Objective This subject studied the change and correlation of smell during the preparation process of Rhizoma Gastrodiae herb-pieces-extract-formula granules. A new overall evaluation index of preparation process was attempted to introduce, aimed to investigate a preparation process of Chinese medicinal granules which is in line with the overall concept of Chinese Medicine. Methods The smell data of all samples were collected use an electronic nose technology. Then the characteristic data was analyzed through statistical methods such as principal component analysis (PCA), discriminant factor analysis (DFA) and statistical quality control (SQC). Results The loss of gastrodin’s smell is very small during the preparation process of herb-pieces-extract; while the loss during extract-formula granules process is bigger. This prompted that it was feasible to evaluate the technology of TCM formula particles according to the existing mode of chemical drugs, but it is different from the evaluation results which used the smell that is in line with the overall concept of Chinese Medicine as evaluation index. Conclusion The electronic nose technology can be used for collecting smell data of the gastrodin samples (different forms). Through data analysis with different models, the difference and correlation between different samples of gastrodin’s smell could be identified. The smell can be used as the overall evaluation index during the preparation process of Gastrodiae Rhizoma formula granule.

基金项目：国家“十二五”科技支撑计划资金资助（2012BAI29B11）；中央高校基本科研业务费专项资金资助（SWJTU12CX051，SWJTU11ZT26）