[关键词]
[摘要]
目的 以流变学参数弹性模量(G')、黏性模量(G″)、屈服应力(τ0)、蠕变柔量[J(t)]及损耗系数(tanδ)作为评价指标,优化祖师麻凝胶贴膏剂(Daphnes Giraldii Cortex gel plaster,DGCGP)混合工艺。方法 采用正交设计,选用L9(34)正交试验表,以物料混合时的温度、转速以及混合时间为考察因素,以混合后含药胶料的各项流变学参数为评价指标,筛选出DGCGP最佳的混合工艺,并预测适合的涂布条件。结果 优选的DGCGP混合工艺为混合温度70℃,转速10 r/min,时间2 h,在此条件下,混合胶料的黏弹性、耐温耐剪切性、抗变形能力以及稳定性均良好。结论 采用优化工艺条件制备的DGCGP外观良好,且质地柔软,黏弹性好,质量较佳。
[Key word]
[Abstract]
objective To optimize the mixing technology of Daphnes Giraldii Cortex gel plaster (DGCGP) by using rheological parameters elastic modulus (G'), viscous modulus (G″), yield stress (τ0), creep compliance[J(t)] and loss coefficient (tanδ) as evaluation indexes. Methods Using orthogonal design, L9(34) orthogonal design was used to screen out the best mixing technology of DGCGP and predict the suitable coating conditions by taking the temperature, rotating speed and mixing time of the mixed materials as influencing factors and the rheological parameters of the medicated compound as evaluating indexes. Results The optimum DGCGP mixing process was as following:70℃ at 10 r/min for 2 h. Under this condition, the viscoelasticity, temperature and shear resistance, deformation resistance and stability of the mixture were all good. Conclusion DGCGP prepared by this optimized process had good appearance, soft texture, good adhesion with skin, good viscoelasticity and better quality.
[中图分类号]
R283.6
[基金项目]
甘肃省基础研究创新群体项目(1506RJIA034)