药性四气为中药的基本属性，揭示中药药性理论的科学内涵，是目前中医药研究热点之一，也是中医药自身理论研究的基础和客观要求。由于各单味药药性是在漫长的历史时期不断归纳、总结、变化的最终结果，因此明确各单味药的药性形成过程及其影响因素，是中药药性科学内涵研究和共性特征归纳总结的基础条件。通过考证历代古籍文献，结合现代中医药科学研究成果，梳理金银花药性形成过程中的影响因素对其药性最终确立的影响，总结金银花药性成因及其科学内涵。即金银花单味药药性形成是其药效物质基础、临床治疗过程中所体现出来的药效作用和历代临床用药倾向3者综合作用的结果。并在上述研究基础上，首次提出单味药药性成因假说，为中药药性理论研究提供参考。

The four natures are the basic properties of Chinese materia medica (CMM). At present, it is one of the research hotspots to reveal the scientific connotation of CMM property theory. Clarifying the formation process and influencing factors of the medicinal properties of each single herb in a long historical period is the basic condition for the induction and summary of common characteristics of TCM property theory. Through the textual research of ancient books and documents, combined with the research results of modern Chinese medicine science, this paper combs the influence factors in the formation of the medicinal properties of Lonicera japonica, and reveals its scientific connotation. That is to say, the formation of the medicinal properties of each single herb of TCM is the result of its efficacy material base, the efficacy reflected in the process of clinical treatment and the tendency of clinical medication in previous dynasties. Based on the above research, the cause hypothesis of single herb property is put forward for the first time. The hypothesis provides a reference for the theoretical study of medicine property of TCM.

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吉林省重点科技研发项目（20180201056NY）；吉林省医药健康领域项目（20200404031YY）；吉林省教育科学"十三五"规划项目（GH170568）；通化师范学院高等教育教学改革研究项目（JY2017029）