进入新世纪的头20年，2次冠状病毒"光顾"中国，现正处于疫情控制的关键时间，中医药防控疫情的成绩显示了中医药和中西医结合的优势和贡献。鉴于冠状病毒感染后患者临床表现的复杂性以及对器官组织损伤和功能损伤，甚至衰竭的多样性，成为基于临床防治需求研究和应用中药的难题。在梳理中药方剂和单味药研究基础上，从认识冠状病毒感染和致病性及其所致多器官功能障碍与衰竭的原因出发，立足重视中药科学研发与应用，讨论中药对新型冠状病毒（SARS-CoV-2）感染的治疗作用，提出基于可能的"靶标"设计新药研发的框架，通过感染的分子机制拓展新药研究思路。

In the first 20 years of the new century, two times of coronavirus "visiting" China has become a public health emergency, which has attracted great attention at home and abroad. At the critical time of epidemic prevention and control in SARS-CoV-2 infection, the excellent achievements of traditional Chinese medicine (TCM) show the advantages and contributions of TCM. In view of the complexity of the symptoms of patients with coronavirus infection, the diversity of organ and tissue damage and functional damage or failure, how to adapt to the needs of clinical prevention and treatment is not only a problem of modern medicine, but also a problem of TCM. In this review article, the authors combed the research of TCM prescription and single medicine after understanding the cause of coronavirus infection and pathogenicity and multiple organ dysfunction and failure caused by coronavirus. Based on the emphasis on the TCM scientific research and application, the TCM therapeutic effect on SARS-CoV-2 infection is discussed. The framework of new drug research and development based on possible "target" is proposed, and we put forward the ideas for researching new TCM products through the expanding molecular mechanism of infection.

R183.3;R285.6