[关键词]
[摘要]
结核病是全球发病率和死亡率较高的疾病之一,面对越来越严峻的挑战,寻找新途径、新思路研发抗结核病新药是战胜结核病的关键。生物碱类化合物在天然产物中分布广泛,具有生物来源多样性、化学结构多样性和生物活性多样性等特点,大多生物碱类化合物具有抗结核病的活性。综述近年来生物碱类化合物抗结核病作用及其相关机制的研究进展,以期总结不同类型生物碱抗结核病的特点,为该类化合物抗结核病的进一步深入研究与开发利用提供参考。
[Key word]
[Abstract]
Tuberculosis is one of the diseases with high incidence and mortality in the world. In the face of the increasing severe challenges of tuberculosis, there is a key to fight against tuberculosis by finding new ways and new ideas to develop new anti-tuberculosis drugs. Alkaloid compounds are widely distributed in natural medicines, which have the characteristics of biodiversity, chemical structure diversity and biological activity diversity, and most alkaloids have anti-tuberculosis activity. This article reviews the research progress of the effects of alkaloids on tuberculosis and the mechanism of anti-tuberculosis in recent years, which may summarize the characteristics of different types of alkaloids against tuberculosis and provide reference for further research, development and utilization of these compounds against tuberculosis.
[中图分类号]
R285
[基金项目]
重庆市卫生局医学科学技术研究项目(2010-2-330);重庆市中医药科技项目(ZY201702045);重庆市科卫联合医学科研项目(2018QNXM043);重庆市公共卫生医疗救治中心青年科研创新基金项目(2019QNKYXM02)