[关键词]
[摘要]
目的 研究元宝草共生菌球毛壳霉Chaetomium globosum发酵产物的化学成分。方法 采用正、反相硅胶柱色谱,凝胶sephadex LH-20柱色谱,高效液相色谱等方法进行系统分离纯化,根据化合物的理化性质,借助核磁共振等方法鉴定化合物的结构。结果 从球毛壳霉发酵产物的乙醇提取液中共分离鉴定了8个化合物,分别鉴定为glolactoneA(1)、4'-epialtenuene(2)、交链孢霉烯(3)、chaetomugilinQ(4)、chaetomugilin D(5)、chaetomugilide B(6)、chaetoglobosinVb(7)、chaetoglobosinC(8)。结论 化合物1为新化合物,命名为球毛壳内酯A,化合物2和3为首次从该菌中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of fungus Chaetomium globosum isolated from Hypericum sampsomii. Methods By means of silica gel, Sephadex LH-20 column chromatography, and HPLC, the chemical constituents of solid culture broth of C. globosum were separated systematically. The structures of the isolated compounds were elucidated by means of physico-chemical properties and spectral data. Results By means of spectroscopic evidences, eight compounds were isolated from the 95% ethanol extract part of the fungus C. globosum, which were identified as glolactone A (1), 4'-epialtenuene (2), altenuene (3), chaetomugilin Q (4), chaetomugilin D (5), chaetomugilide B (6), chaetoglobosin Vb (7), and chaetoglobosin C (8), respectively. Conclusion Compound 1 is a new compound named glolactone A, and compounds 2 and 3 are isolated from this fungus for the first time.
[中图分类号]
R284.1
[基金项目]