[关键词]
[摘要]
目的 研究引种植物西印度醋栗Phyllanthus acidus叶的化学成分。方法 采用硅胶、Sephadex LH-20凝胶等柱色谱方法及制备液相色谱技术分离纯化,运用核磁共振波谱、质谱等谱学技术结合理化性质鉴定化合物结构。结果 从西印度醋栗叶醇提物中分离得到10个化合物,分别鉴定为3α-桂皮酰氧基熊果-20(29)-烯-18β-醇(1)、叶下珠醇(2)、山楂酸(3)、米念芭素E(4)、槲皮苷(5)、对羟基苯甲酸(6)、4-羟基苯乙酸甲酯(7)、4-O-葡萄糖基苯甲酸(8)、硫代乙酐(9)、L-焦谷氨酸(10)。结论 化合物1为新化合物,命名为醋栗叶醇;3~10均为首次从西印度醋栗中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents of the leaves of Phyllanthus acidus. Methods All compounds were isolated by silica gel and Sephadex LH-20 gel column chromatographies as well as semi-preparative HPLC, and their structures were elucidated on the basis of physicochemical properties and spectral data. Results Ten compounds were isolated and identified as 3α-cinnamoyloxyurs-20(29)-en-18β-ol (1), phyllanthol (2), maslinic acid (3), ovoideal E (4), quercetin-3-rhamnoside (5), 4-hydroxybenzoic acid (6), methyl 4-hydroxyphenylacetate (7), 4-O-(β-glucopyranosyloxy)-benzoic acid (8), thioacetic anhydride (9), L-pyroglutamic acid (10). Conclusion Compound 1 is a new compound named as phyllanacidol B, and compounds 3-10 are obtained from P. acidus for the first time.
[中图分类号]
R284.1
[基金项目]
国家重点研发计划(2019YFC1711000);江苏省科技基础设施建设计划(BM2014047)