藏药波棱瓜Herpetospermum caudigerum子是藏医临床治疗肝胆疾病的常用药物之一。现代研究表明，波棱瓜子具有保肝降酶、抗乙肝病毒及抗肝纤维化等药理作用，其抗肝病主要药效物质为木脂素类成分；脂肪酸类、多糖类等成分也有一定的保肝降酶活性。对波棱瓜子抗肝病药效物质基础、药理作用及制剂研究等方面的研究进展进行综述，以期为波棱瓜子在抗肝病中的研究、应用及制剂开发提供借鉴和思考，促进民族医药的现代研究与发展。

Semen Hertospermi (Bolengguazi in Chinese, BL), as well-known Tibetan medicine, is one of commonly used drugs by Tibetan healers for the treatment of liver diseases and cholic diseases. Modern research indicated that BL had multiple pharmacological effects including hepatoprotection, anti-hepatitis B virus and anti-liver fibrosis, etc. And the lignans are the major pharmacodynamic substances. The fatty acid, polysaccharides and other ingredients also have hepatoprotective effects. This article mainly reviews the pharmacodynamic substances, pharmacological effects, preparation research and development related to anti-liver disease, so as to provide reference and thinking for the research and application of BL and preparations development in the prevention of liver disease and promote the modern research and development of ethnic medicine.

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国家自然科学基金资助项目（81573697）；国家自然科学基金资助项目（81873692）；国家重大新药创制（2016ZX09101073）