[关键词]
[摘要]
乙酰胆碱酯酶抑制剂是阿尔茨海默病治疗药物的研究热点,按来源可分为化学合成和天然产物两大类。生物碱为天然乙酰胆碱酯酶抑制剂的重要来源。通过文献回顾,从结构类型、作用机制及其构效关系等方面综述了植物来源具有乙酰胆碱酯酶抑制活性的生物碱的研究进展,以期为天然生物碱来源的乙酰胆碱酯酶抑制剂的研发提供参考和借鉴。
[Key word]
[Abstract]
Acetylcholinesterase (AChE) inhibitor is research hotspot for the treatment of Alzheimer's disease (AD), which can be divided into two categories, chemical synthesis and natural products, according to its sources. Alkaloids are important sources of natural AChE inhibitors. In this paper, the research progress of plant-derived alkaloids with the inhibitory activity of AChE was reviewed from the aspects of structure type, mechanism of action and structure-activity relationship, in order to provide reference for the research and development of AChE inhibitors derived from natural alkaloids.
[中图分类号]
R284;R285
[基金项目]
国家自然科学基金项目(31260082);国家自然科学基金项目(31760099)