[关键词]
[摘要]
目的 研究灰毡毛忍冬Lonicera macranthoides花蕾中的苷类化学成分。方法 采用HP-20、硅胶、ODS、SephadexLH-20和制备液相等多种色谱学方法进行分离纯化,并通过理化常数和各种波谱技术鉴定化合物的结构。结果 从灰毡毛忍冬干燥花蕾70%乙醇提取物中分离得到了8个化合物,分别鉴定为7,3',4'-三甲氧基槲皮素-3-O-α-L-吡喃阿拉伯糖基-(1→6)-O-β-D-吡喃葡萄糖苷(1)、7,3',4'-三甲氧基槲皮素-3-O-芸香糖苷(2)、槲皮素-3-O-β-D-吡喃葡萄糖苷(3)、坎卡酯苷(4)、kankanosideE(5)、betulalbuside A(6)、shomaside F(7)、amarantholidoside V(8)。结论 化合物1为新化合物,命名为甲氧基槲皮素苷;化合物5~8为首次从忍冬属植物中分离得到。
[Key word]
[Abstract]
Objective To study the glycosides from the 70% ethanol extract of Lonicera macranthoides. Methods The compounds were isolated and purified by column chromatography of HP-20 macroporous resin, silica gel, ODS, Sephadex LH-20, and semi-preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analyses. Results Eight compounds were isolated and identified as 7,3',4'-trimethoxylquercetin-3-O-α-L-arabinadosyl-(1→6)-O-β-D-glucopyranoside (1), 7,3',4'-trimethoxylquercetin-3-O-rutoside (2), quercetin-3-O-β-D-glucopyranoside (3), (2E,6S)-8-[α-L-arabinopyranosyl-(1"→6')-β-D-glucopyranosyl]-2,6-dimethyloct-2-eno-1,2"-lactone (4), kankanoside E (5), betulalbuside A (6), shomaside F (7), and amarantholidoside V (8), respectively. Conclusion Compound 1 is a new compound named methoxylquercetinside, while compounds 5-8 are isolated from the genus of Lonicera for the first time.
[中图分类号]
R284.1
[基金项目]
国家自然科学基金重点项目(81630097);国家中医药管理局中药标准化建设项目(ZYBZH-C-JS-31);国家中医药管理局中药标准化建设项目(ZYBZH-C-JS-28)