[关键词]
[摘要]
黄芩苷是源于中药黄芩的黄酮类成分,其药理活性明显。研究表明,黄芩苷可用于治疗肺炎、肿瘤及肝炎等疾病。但黄芩苷较差的水溶性和脂溶性导致其生物利用度低,限制了其临床疗效的发挥。因此,近年来利用新技术制备黄芩苷新剂型以改善其物理特性的研究逐步深入。基于此,综合国内外相关文献,对黄芩苷药理作用和新剂型的研究进展进行综述,以期为黄芩苷的应用和研究提供参考。
[Key word]
[Abstract]
Baicalin is a kind of flavonoids derived from Scutellaria baicalensis with obvious pharmacological activities. Studies have shown that baicalin can be used in the treatment of pneumonia, tumor and hepatitis and other diseases. However, the poor water solubility and liposolubility of baicalin lead to the low bioavailability of it, which limits the clinical efficacy of baicalin. Therefore, in recent years, new dosage forms of baicalin have been prepared by new technology to improve its physical properties. Based on this, this paper reviews the research progress of pharmacological action and new dosage forms of baicalin based on the relevant literatures at home and abroad, in order to provide reference for the application and research of baicalin.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81673615);四川省中医药管理局项目(2018QN009);成都中医药大学校级科研基金资助项目(QNXZ2018018);全国中药特色技术传承人才培训项目(T20194828003);四川省人力资源和社会保障厅项目(00809503)