目的 探讨布渣叶总黄酮（total flavones from Microcos paniculata，MPTF）的高效绿色环保提取方法，并考察其调血脂活性。方法 采用离子液体协同超声辅助提取MPTF，对提取工艺进行单因素实验及正交试验考察；采用高脂饲料造模，将Wistar大鼠随机分为正常对照组、阳性对照组（瑞舒伐他丁钙片5.2 mg/kg）、高脂模型组和MPTF低、中、高剂量组（ig给药MPTF 300、600、900 mg/kg），每组各10只，测定总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）水平。结果 离子液体超声辅助提取MPTF的最佳工艺条件：离子液体为[BMIM]Cl，浓度为0.30 mol/L，料液比为1：40，提取溶剂为60%乙醇水溶液，提取时间为30 min，提取温度为50℃；验证实验结果表明，该提取工艺所得总黄酮提取率高，工艺稳定。调血脂实验结果表明，MPTF各剂量组均能够降低TC、TG、LDL-C水平，升高HDL-C水平（P<0.05），且随着MPTF剂量增加各指标变化趋势明显，具有一定的剂量依赖性。结论 离子液体协同超声辅助提取MPTF工艺稳定可行，为离子液体协同超声辅助提取中药中难溶性有效成分提供参考；MPTF提取物具有较好的调血脂作用。

Objective To explore the high-efficiency green environmental extraction method of total flavones from Microcos paniculata (MPTF), and investigate its lipid-lowering activity. Methods The ionic liquid was used to assist the ultrasonic extraction of MPTF, and the extraction process was investigated by single factor experiment and orthogonal test. Wistar rats were randomly divided into normal control group and positive control group (Resuvastatin Calcium Tablets 5.2 mg/kg) by high fat diet, high-fat model group and MPTF low, medium and high dose groups (ig dose MPTF 300, 600, 900 mg/kg), with 10 rats in each group. The total cholesterol (TC), glycerol lipid (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) levels were determinated. Results The optimum process conditions for ultrasonic-assisted extraction of MPTF by ionic liquid were as follow:ionic liquid was[BMIM]Cl at concentration of 0.30 mol/L; ratio of material to liquid was 1:40, extraction solvent was 60% ethanol aqueous solution with extraction time of 30 min at 50℃. The verification test results showed that the extraction rate of total flavonoids obtained from the extraction process was high and the process was stable. The results of lipid-lowering test showed that the levels of TC, TG and LDL-C were decreased in all doses of MPTF groups, and the level of HDL-C was increased (P<0.05). With the increase of MPTF dose, the indicators showed obvious trends in a dese-dependent manner. Conclusion The ionic liquid combined with ultrasonic-assisted extraction of MPTF is stable and feasible, which provides reference for ionic liquid synergistic ultrasound-assisted extraction of poorly soluble active ingredients in Chinese materia medica. MPTF extract has better lipid-lowering effect.