海洋天然产物是现代海洋药物的泉源，但其先导性强、成药性弱。如何快速、高效地发现新的活性海洋天然产物并进行成药性优化是海洋创新药物研发的重要思路。为此，从海洋天然产物的生源与特点、其特异生产力海洋微生物及其丰产与优产策略、海洋天然产物的成药性改造等方面进行探讨，并提出了相关建议。

Marine natural products (MNPs) are the source of modern marine drugs, but they have the characteristics of strong guiding function and weak druggability. How to quickly and efficiently discover new bioactive MNPs and optimize their druggability is an important idea for the research and development of innovative marine drugs. This article has made some discussions and suggestions on this emphasis from the origin and characteristics of MNPs, marine microorganisms with specific productivity for MNPs and the strategies of microbial MNPs with high yields and diverse structures, as well as the structural modification for medicinal use of MNPs.

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国家自然科学基金资助项目（41876172）；国家自然科学基金资助项目（U1501221）