[关键词]
[摘要]
苯乙醇苷(PeGs)是众多药材中的天然活性成分,具有抗氧化、保肝、美白、神经保护等多方面的作用。然而,药材中PeGs含量低且不稳定。近年来,为获得富含PeGs的药材,PeGs生物合成及代谢调控方面的研究被广泛开展。对PeGs在植物和微生物中生物合成与代谢调控研究及其化学全合成和半合成研究进行综述,以期为阐明PeGs的生物合成机制,稳定并提高植物药材中PeGs的含量、提升药材品质,综合利用微生物代谢工程法或化学合成法合成PeGs提供参考。
[Key word]
[Abstract]
Phenylethanoid glycosides (PeGs) are natural active ingredients of many plants at home and abroad. They possess a spectrum of beneficial activities, such as anti-oxidant, hepatoprotective, whitening, and neuroprotective. However, the content of PeGs in food or medicinal materials is low and unstable. During the past decade, studies on biosynthesis and metabolic regulation of PeGs have been extensively carried out. Here, the recent achievements in biosynthesis and metabolic regulation of PeGs in plants and microorganisms are reviewed, as well as in total synthesis and semi-synthesis of PeGs. Hopefully, this work done so far will provide reference for elucidating the biosynthesis mechanism of PeGs, stabilizing and improving the content of PeGs in herbal materials, improving the quality, and synthesizing PeGs by microbial metabolic engineering or chemical synthesis.
[中图分类号]
[基金项目]
安徽省高校优秀青年人才支持计划项目(gxyqZD2019111);安徽省高等学校自然科学研究项目(KJ2019A1202);省级质量工程教学研究项目(2018jyxm0159)