[关键词]
[摘要]
蒲黄为传统平性活血化瘀药,主要含有黄酮、烷烃、有机酸、多糖、挥发油等类化学成分,《中国药典》2015年版以香蒲新苷和异鼠李素-3-O-新橙皮苷作为蒲黄的指标成分。通过对蒲黄的资源分布、化学成分、药理活性进行分析总结,进而分析蒲黄中黄酮类、多糖类、挥发油等主要成分与药效的关系,并在此基础上,基于质量标志物(Q-marker)核心概念分析其生源途径、传统作用、药理作用与化学成分之间的关系,对蒲黄的Q-marker进行预测分析,提出应进一步深入研究其黄酮类、多糖类和挥发油等化学物质组,对蒲黄中黄酮类、多糖类、挥发油等成分进行定性、定量分析,为建立和完善其药材和饮片质量标准提供依据。
[Key word]
[Abstract]
Typhae Pollen, a well-known traditional Chinese medicine with neutral property, is mainly chemical composition including flavonoids, alkane, organic acid, polysaccharides, volatile oil, etc. Traditionally, typhaneoside and isorhamnetin-3-O-neohesperidoside from flavanol are its main effective components. In this paper, the resource, chemical composition and pharmacological activities of Pollen typhae were summarized. And on this basis, the relationship between chemical composition and drug efficacy, including the flavonoids, polysaccharides, volatile oil, as well as the relationships among biogenetic ways, traditional efficacy, modern pharmacological effects and chemical composition were analyzed. It is suggested that identification and quantification of flavonoids, polysaccharides, volatile oil should be carried out and further research of the chemical group of flavanol, polysaccharides, volatile oil from Typhae Pollen should be focused, which could provide basis for clarifying the quality marker (Q-marker) and establishing scientific quality standards of Typhae Pollen.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81560658);广西科技计划项目(17-259-20);广西科技计划项目(桂科AD17195025);广西科技计划项目(桂科AB17195019);研究生教育创新计划项目立项课题(YJS18073);研究生教育创新计划项目立项课题(YJS18073)