[关键词]
[摘要]
中药具有化学成分复杂、成分结构多样、生物活性多样等特点,单一化合物无法准确反映中药的质量和药效特点,多成分、多指标、多影响因素的综合评价在中药研究领域得到了越来越广泛的应用。如何综合分析多成分、多指标、多影响因素评价结果是中药复杂体系研究存在的主要问题之一。雷达图是目前应用较为广泛的多指标综合评价方法之一,因其在形式上与蜘蛛网有极高的相似性,本课题组提出了"蛛网"模式("spider-web" mode)的概念,并将其应用于中药质量标志物的筛选、中药质量评价、稳定性、活性成分筛选等研究中。对"蛛网"模式及雷达图在中药研究中的应用开展系统综述,总结"蛛网"模式的优点、特点、应用领域,以期"蛛网"模式能更好地服务于中药研究。
[Key word]
[Abstract]
Chinese materia medica (CMM) is characterized with complicated components, diverse structures and multiple activities, whose quality and efficacy are difficult to display only by detection of single component. The comprehensive evaluation is greatly applied in CMM research by integrating assessment of multi-components, multi-indexes and multi-influence factors, and the challenge of which is how to choose the suitable method for data analysis. Radar chart is one of the most widely used multi-index comprehensive evaluation methods. Because of its high similarity with spider web in form, the concept of "spider-web" mode was put forward and used in the screening of quality marker (Q-maker), the quality evaluation of CMM, the stability study, the selection of bioactive components, and so on. In order to preferably apply the "spider-web" mode in CMM study, this paper systematically summarized the application of "spider-web" mode and radar chart in CMM and introduced its advantages, characteristics and application fields.
[中图分类号]
[基金项目]
国家自然科学基金面上项目(81873192)