[关键词]
[摘要]
中药质量是中医药应用、发展和传承的重要因素,是中药发挥临床疗效的保障。长期以来,具有复杂性和多样性特征的中药,特别是由多种中药组成的复方中药药效物质基础尚不明确,限制了其质量标准的制定,影响了中医药国际化的进程。质量标志物主要依据中药属性、制造过程及配伍理论等特点提出,是中药及中药复方质量评价的指标性成分。近些年来关于质量标志物的解析和应用研究得到了迅猛的发展,为质量标准的制定提供更加科学、明确的方向。从中药方剂整体观研究体系出发,围绕中药复方的药理活性以及相关化学物质基础、整合系统生物学和网络药理学的前沿技术,对质量标志物的发现进行综述,介绍相关经验方法和研究进展,以期为发现与临床疗效相关的药效成分即质量标志物提供丰富有益的方法指导。
[Key word]
[Abstract]
The quality of Chinese material medica (CMM) is an important factor in the application, development, and inheritance of traditional Chinese medicine (TCM). It is also the guarantee of the clinical efficacy of CMM. For a long time, the pharmacodynamics material basis of CMM with the characteristics of complexity and diversity, especially CMM formula composed of many kinds of Chinese materia medica, is still unclear. It limits the scientific formulation of quality standards and affects the process of internationalization of TCM. Quality markers are proposed based on the properties, manufacturing process, and compatibility theory of TCM, which are the indicators of quality evaluation of CMM and its formula. In recent years, the research and application of quality markers has developed rapidly, which provides a more scientific and clear direction for the formulation of quality standards. This paper reviews the discovery of quality markers based on the holistic research system of CMM formula, focusing on its pharmacological activity and related chemical substance basis, integrating the frontier technologies of system biology and network pharmacology, and introduces the relevant experience, methods, and research progress, with a view to discovering the correlation with clinical efficacy. The quality markers of CMM could provide abundant and useful methodological guidance.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81520108030);国家自然科学基金资助项目(21472238)